Kinesin-related protein

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August undefined, 2024

Web1 feb. 2011 · The authors show that mutation of the rice gene encoding the kinesin-like protein BC12/GDD1 causes a significant reduction in the endogenous GA level and in cell elongation. This is a result of direct regulation of the expression of KO2, a key gene in GA biosynthesis, by GDD1 binding to the KO2 promoter. Web1 nov. 2009 · The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell. 1995; 81 (5):769–80. [Google Scholar] Rashid DJ, Bononi J, Tripet BP, Hodges RS, Pierce DW. Monomeric and dimeric states exhibited by the kinesin-related motor protein KIF1A.

Kinesin Related Proteins – Kinesin - Duke University

Web18 nov. 1993 · We report here that kinesin-related genes encode the 85K and 95K subunits, and that the protein can be immunoprecipitated from cytosol as a trimeric … WebKinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. … scan qr code with iphone 11

Kinesin superfamily motor proteins and intracellular transport

Web12 apr. 2024 · 1 INTRODUCTION. Gigaxonin is a ubiquitously expressed protein encoded by the GAN gene located on human chromosome 16q24.1. 1, 2 The lack or loss of function of gigaxonin causes giant axonal neuropathy (GAN), an autosomal recessive disorder. The GAN gene has more than 50 distinct loss of function mutations that cause the disorder. 3 … WebWe focus on producing highly pure and biologically active kinesin and myosin family proteins of eukaryotic and fungal origin. These reagents are intended for anti-mitotic drug discovery and mechanistic studies of motor … Web1 jul. 1992 · We identified two new Saccharomyces cerevisiae kinesin-related genes, KIP1 and KIP2, using polymerase chain reaction primers corresponding to highly conserved regions of the kinesin motor domain. Both KIP proteins are expressed in vivo, but deletion mutations conferred no phenotype. Moreover, kip1 kip2 double mutants and a triple … ruc ecu worldwide

WO1998058064A1 - Kinesin-related protein - Google Patents

The functions of kinesin and kinesin-related proteins in eukaryotes

WebNCI at Frederick: Search ... Skip Navigation Web13 okt. 2024 · The Yeast Kinesin-related Protein Smy1p Exerts Its Effects on the Class V Myosin Myo2p via a Physical Interaction Molecular Biology of the Cell Molecular Biology of the Cell Vol. 11, No. 2 Articles Free Access The Yeast Kinesin-related Protein Smy1p Exerts Its Effects on the Class V Myosin Myo2p via a Physical Interaction Karen … ruc forli scan qr code with iphone 13

"WebImmunochemical evidence for kinesin-related proteins in ﬂagella To identify kinesin-related proteins in ﬂagella, we used the affinity-puriﬁed polyclonal antibodies to the LAGSE and HIPYR peptides corresponding to conserved sequences in the motor domain of kinesin as described by Sawin et al. (1992a). " - Kinesin-related protein

Kinesin-related protein

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a type of enzyme). The active movement of kinesins supports several … Meer weergeven Kinesins were discovered in 1985, based on their motility in cytoplasm extruded from the giant axon of the squid. They turned out as MT-based anterograde intracellular transport motors. The founding … Meer weergeven Overall structure Members of the kinesin superfamily vary in shape but the prototypical kinesin-1 motor consists of two Kinesin Heavy Chain (KHC) molecules which form a protein dimer (molecule pair) that binds two light chains … Meer weergeven In 2024 direct visualization of kinesin "walking" along a microtubule, in real-time was reported. In a "hand-over-hand" mechanism, the kinesin heads step past one another, alternating the lead position. Thus in each step the leading head becomes … Meer weergeven In recent years, it has been found that microtubule-based molecular motors (including a number of kinesins) have a role in mitosis (cell division). Kinesins are important for proper spindle length and are involved in sliding microtubules apart within the … Meer weergeven In the cell, small molecules, such as gases and glucose, diffuse to where they are needed. Large molecules synthesised in the cell … Meer weergeven Motor proteins travel in a specific direction along a microtubule. Microtubules are polar; meaning, the heads only bind to the microtubule in one orientation, while ATP binding gives each step its direction through a process known as neck linker zippering. Meer weergeven A number of theoretical models of the molecular motor protein kinesin have been proposed. Many challenges are encountered in theoretical investigations given the … Meer weergeven WebRon Vale explains the inner workings of the motor protein called kinesin (“kin-EE-sin”) that transports vital components within cells and also separates chromosomes during cell division. He...

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WebKinesins are ATP-dependent motor proteins that can generate force and displacement along microtubules. They play key roles in mitosis and in the trafficking of organelles … WebBackground: Kinesin family member 4A (KIF4A) is upregulated in a variety of cancers. However, its expression and potential downstream targets in urothelial bladder …

Web5 aug. 2015 · This family represents a region within kinesin-related proteins from higher plants. Many family members also contain the pfam00225 domain. Kinesins are ATP … Web25 jul. 2024 · The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells.

Web25 sep. 2024 · It is found that the kinesin-related protein TBK11 clearly localized to the nuclear envelope throughout the cell cycle in BY-2 cells by dual localization studies using fluorescent proteinfused TBK 11 and inner nuclear membrane protein SUN. Nuclear movement and positioning are important for various plant growth and development events. Web5 mrt. 2024 · Kinesin-1 is a processive motor protein that uses ATP-derived energy to transport a variety of intracellular cargoes toward the cell periphery.

Web11 apr. 2024 · Figure EV1 (related to Fig 3). ... It was recently demonstrated that Ab10 knob transport is mediated by Kindr encoded KINDR, a minus-end-directed motor protein that diverged from a Kinesin 14A ancestor and specifically interacts with 180-bp knob repeats (Dawe et al, 2024).

WebMonastrol potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition). PC-45861: Ispinesib. 336113-53-2: Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM. PC-49614: AM-5308. 2410796-89-1 ruc elizabethWebThe kinesin motor protein family consists of 14 distinct subclasses and 45 kinesin proteins in humans. A large number of these proteins, or their orthologues, have been shown to possess essential function(s) ... Kinesin Related Products (24) Kinesin Isoform Comparison; Kinesin Related Products (24): Cat. No. Product Name Effect Purity; HY … ruc fisholgWebThe Drosophila kinesin-like protein KLP67A is a microtubule plus-end-directed depolymerase that regulates microtubule length during both mitosis and male meiosis and is essential for spindle assembly and cytokinesis. Hemizygous males with reduced levels of KLP67A are almost completely sterile. rucer busWeb30 mrt. 2024 · PLK (STPK13) encodes a murine protein kinase closely related to those encoded by the Drosophila melano-gaster polo gene and the Saccharomyces cerevisiae CDC5 gene, which are required for normal mitotic and meiotic divisions. Affinity-purified antibody generated against the C-terminal 13 amino acids of Plk specifically recognizes … scan qr code with kindle fireWebI created this animation of the molecular motor "kinesin" walking along a protofilament of a microtubule in 1999 for the Ron Milligan and Ron Vale Science pa... scan qr code with iphone 12WebM phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. J. Biol. Chem. 278, 27844-27852. Question 1: How pure does my kinesin protein need to be to utilize the ATPase assays? ruc food retailWebKinesin-related protein Abstract The invention provides a human kinesin-related protein (KINRELP) and polynucleotides which identify and encode KINRELP. The invention also provides expression... ruc fanny