Klf4 senescence
WebOct 8, 2024 · KLF4 mediates the recruitment of JMJD3 to the enhancers and promoters of these genes, where both factors cooperate with p300, cohesin, mediator, and other co-regulators, in particular the cohesin... Webmodulators, moderators of cell senescence, or modulators of metabolism [3, 34, 35] and the functions of the small ... levels of OCT4 and KLF4 during somatic cell reprogram-ming [32]. Parnate, a lysine-specific demethylase inhibitor (LSD1),mediatesH3K4demethylation,enablingOct4and
Klf4 senescence
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WebDec 10, 2024 · This is dictated in part by upregulation of KLF4 signaling. Therefore, inhibiting hyperoxia-induced senescence via miR-34a-5p or KLF4 suppression may provide a novel … WebDec 13, 2024 · KLF4, a DNA-binding transcriptional regulator, controls a large number of key cellular processes and regulates cell senescence and survival in response to cellular …
WebMay 31, 2016 · There are of course also reports that show opposite outcomes, i.e. faster aging: Senescence was accelerated in 3 cloned pigs of a genetically abnormal fetal fibroblast cell line . Genetic dysregulation also led to phenotypical abnormities in G0 and G1 generations of serial cloned pigs, but generations G2 and G3 were back to normal again [ … WebDec 15, 2024 · FIGURE 2.Hyperglycemia-induced HUVEC senescence is KLF4 dependent. (A) KLF4, as measured by immunoblotting and qRT-PCR in HUVECs after transfection with siNC or siKLF4 for 48 h.(B) Cells were fixed and stained for SA-β-gal activity and the histogram represents the percentage of SA-β-gal-positive cells per microscopic field. Values …
WebSep 21, 2024 · KLF 4 can activate P21 in a P53-dependent manner ( Zhang et al., 2000 ). In addition, It was found that KLF 4 (–/–) cells entered senescence phase earlier than KLF 4 (+/+) cells, which can be explained by the less antioxidant gene expression and higher reactive oxygen species (ROS) level in KLF 4 (–/–) cells. WebIn order to determine whether KLF4 is involved in Hcy-induced endothelial cell senescence, western blotting and RT-qPCR were used to assess the expression levels of KLF4. As …
WebFeb 17, 2024 · Expressions of KLF4, PDGF-BB, PDGFRA and PDGFRB in normal and senescent HUVECs were assessed by mRNA-seq and protein microarray. KLF4/PDGF …
WebSenescence analysis was performed by β-galactosidase staining after 24 and 48 h. Controls were established using BM-MSC from healthy donors and used for senescence and gene expression assays. Gene expression was performed using RT-PCR for pluripotency genes, such as SOX2, POU5F1, NANOG, and KLF4. ckn tetraziniWebNov 9, 2014 · T-REx-293 KLF4 and T-REx-HeLa KLF4 cells were seeded into 6-well plates, three days after DOX treatment, cellular senescence was detected by SA-β-Gal staining assay. Bars represent the mean ± SD ... cko osnabrück radiologieWebKLF4 expression during endothelial cell senescence. As previously reported, KLF4 is an evolutionarily conserved zinc finger-containing transcription factor Figure 4. Salidroside can down-regulate the protein expression of p53 and p21 genes. Expression levels of (A) p53 and (B) p21 were determined using western blot analysis. cko kickboxing clark njWebMay 5, 2024 · Klf4 is important in sustaining keratinocytes proliferation; silencing of KLF4 by RNA interference is sufficient to induce cellular senescence. During cellular senescence … cko osnabrück station 7WebDec 22, 2005 · Third, KLF4 was identified in a screen for genes whose products can prevent induction of senescence by an activated form of Ras (Ras V12) 40. Michael Ruppert's laboratory found that KLF4 is... ckojWebOct 23, 2005 · KLF4 ( GKLF / EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a … ckp graniteWebKLF4 regulates many gene expression, thus affects the process of cell proliferation, differentiation, and apoptosis. Recently, KLF4 was reported to induce senescence during the generation of... ckogh