Topbp1 cancer

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August undefined, 2024

WebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. Web20. máj 2024 · Here, we report that TOPBP1 interacts with the RNA-binding protein HTATSF1 in a cell-cycle- and phosphorylation-dependent manner. Mechanistically, CK2 phosphorylates HTATSF1 to facilitate binding to TOPBP1, which promotes S-phase-specific TOPBP1 recruitment to damaged chromatin and subsequent RPA/RAD51-dependent HR, genome …

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Web12. sep 2014 · The expression levels of TopBP1 and Claspin were increased in the cancer cells that survived radiation therapy. Depletion of TopBP1 or Claspin using shRNA showed … shandong zhongsu taifu technology co. ltd

CIP2A interacts with TopBP1 and is selectively essential for

Web1. máj 2024 · TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Web17. nov 2014 · In Akt-hyperactive cancer, TopBP1 forms oligomers and represses E2F1-dependent apoptosis. Here we perform a molecular docking screening and identify a lead … Web25. jan 2016 · TOPBP1 is a large, nine BRCT domain–containing protein with essential roles in cellular processes, including DNA repair, replication, and transcription ( Sokka et al., 2010 ). TOPBP1 enhances ATR kinase activity ( Kumagai et al., 2006) through interaction with ATR partner protein ATRIP ( Mordes et al., 2008 ). shandong zhongyida fitness equipment co. ltd

Functions of TopBP1 in preserving genome integrity during mitosis

Deubiquitinase OTUD6A promotes breast cancer progression by

Web16. mar 2009 · (B) TopBP1 is upregulated through deregulation of the pRb pathway or other mechanisms. Overexpression of TopBP1 in some cancer cells then may inhibit both p53 … WebTOPBP1 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC SUMMARYi Prognostic marker in liver cancer (unfavorable), endometrial … shandong zhulian handcrafts productWebpred 15 minútami · Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year survival rate observed in women with advanced stage disease warranting continued efforts to develop new treatment options. The amplification of BRD4 in a significant subset of high-grade serous ovarian carcinomas (HGSC) has led to the … shandong zhucheng foreign trade group co ltd

"WebPatients were divided based on level of expression into one of the two groups "low" (under cut off) or "high" (over cut off). X-axis shows time for survival (years) and y-axis shows the probability of survival, where 1.0 corresponds to 100 percent. Read more. TOPBP1 is not prognostic in prostate cancer. " - Topbp1 cancer

Topbp1 cancer

A PARylation-phosphorylation cascade promotes TOPBP1

WebTOPBP1 - Explore an overview of TOPBP1, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance … Web31. aug 2024 · Here, we demonstrate that CIP2A is selectively essential for DNA damage-induced initiation of mouse BLBC tumors, but not of other cancer types. Mechanistically, …

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WebTOPBP1 is believed to allosterically activate ATR via its ATR activation domain (AAD), located between BRCT6 and BRCT7 ( 10, 11 ). Recently, Ewing tumor-associated antigen 1 (ETAA1), containing a motif with sequence similarity to AAD, was identified as a second ATR-activator protein ( 15 – 17 ). Web15. aug 2024 · A direct interaction between CIP2A and a DNA repair scaffold protein TopBP1 was identified, and CIP2A inhibition resulted in enhanced DNA damage-induced TopBP1 …

WebTOPBP1 is not prognostic in lung cancer Alive (n=600) Dead (n=394) Female (n=398) Male (n=596) Stage: i (n=8) ia (n=219) ib (n=283) ii (n=4) iia (n=114) iib (n=159) iii (n=3) iiia … Web5. apr 2024 · TopBP1 to be upregulated in breast cancer tissues. TopBP1 overexpression was associated with higher-grade tumors and reduced patient survival (Forma et al., 2012; Going et al., 2007; Liu et al., 2009). p53 is a well-studied tumor suppressor and in the majority of cancers, p53 is mutated leading to gain of function mutations in the

Web28. feb 2007 · Aims: The TopBP1 protein includes eight BRCT domains (originally identified in BRCA1) and has homology with BRCA1 over the carboxyl terminal half of the protein. The aim of this study was to determine whether TopBP1 is aberrantly expressed in breast cancer. Methods and results: Sixty‐one breast carcinomas from an unselected … Web17. nov 2014 · TopBP1 is a protein that binds the enzyme. FULL STORY A compound called calcein may act to inhibit topoisomerase IIβ-binding protein 1 (TopBP1), which enhances the growth of tumors, said...

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WebExpression of TOPBP1 (Dpb11, KIAA0259, TOP2BP1) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. shandong zhushi pharmaceuticalWeb8. jan 2024 · High TopBP1 mRNA and protein expression is associated with endometrial cancer. Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation … shandong zhushi pharmaceutical groupWeb1. mar 2024 · Our finding that the TOPBP1/PARP1 pathway facilitates acquisition of oxaliplatin resistance uncovers a novel mechanism underlying platinum-based … shandongchuanmeiWeb27. okt 2024 · The topbp1 Mutant Seedlings Are Hypersensitive to DSB Induction by Cisplatin Cisplatin is a chemotherapy drug used in different types of cancer [ 19 ]. It produces DNA interstrand crosslinks that can stall replication forks during S phase and thus is very cytotoxic [ 20 ]. shandong zihe vesselWeb1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human … shandongair.com.cnWebTopBP1 also acts as a transcriptional regulator, and we investigated how this activity influenced the HPV life cycle. We determined that TopBP1 levels are increased in cervical … shandongpolyene.comWeb29. jún 2024 · Moreover, high levels of TopBP1 expression have been found in many types of cancer cells; for example, a higher TopBP1 protein level in breast cancer samples was shown to be associated with a ... shandongchinatax.gov.cn